Prof. Dr. Shatha Qasim Jawad, a lecturer at the college of dentistry, has published a valuable scientific research entitled: (Comparison of the Folate and Homocysteine Levels with A80G -RFC1 Gene Polymorphism between the Sample of Iraqi Children with and without Down Syndrome). The aim of the research is to compare homocysteine and folate levels so as to find out the role of polymorphism of the RFC1-A80G Polymorphism gene in a model of children with Down Syndrome and other healthy schoolchildren for the purpose of identifying some genetic and environmental factors of the disease.
The genetic study of the RFC1 gene was conducted and the alleles and genotype and polymorphism of this gene were compared among children who have Down Syndrome with the control group, and the relationship between them and this disease was examined by (Confidence interval 95%) with odd ratio by polymerization technique, and the results showed that the percentage of AG genotype is lower in children who have Down Syndrome but there is no statistically significant difference. The study concluded that the polymorphism of this gene and depending on the results of the OR test that cannot be considered, where no statistically significant difference was found between males and females. Jordan Journal of Biological Sciences (JJBS), V.15, N.2, June 2022.
