Use of Titanium Oxide Nanoparticles to Increase the Production of Prodigiosin and Phenazine from Serratia marcescens and Pseudomonas aeruginosa respectively

Inventor: Assist. Prof. Dr. Laith Ahmed Jacob, Assist. Prof. Dr. Rema Mohammed Abid, Assist. Prof. Dr. Maha Fakhri Majeed, Lecturer. Reem Waleed Younis/Department of Bio-technologies, College of Science, University of Baghdad

Lecturer. Zaid Kazim Abaas/Department of Dormitories, University of Baghdad

Abstract

The present study was designed to investigate the possibility of titanium oxide nanoparticles to enhance the production of both prodigiosin by Serratia marcescens and phenazine by Pseudomonas aeruginosa moreover; poor non-selective nutrient broth was used instead of using selective nutrient broth for the production of both compounds to reduce the economic cost for production. Different concentrations of titanium oxide nanoparticles (0.005, 0.01, 0.015 mg /l) were used in this study to choose the most suitable concentrations to increase production.

Both prodigiosin and phenazine were considered as a promising drug for treating many diseases owing to their characteristics of antibacterial, antifungal, immunosuppressive and anticancer activities. The results revealed that both the prodigiosin and phenazine production was increased from S. marcescens and Pseudomonas aeruginosa when using titanium oxide nanoparticles at (0.01 mg/l) concentration and with a size of 50 nm.