Prof. Dr. Shurook M.K. Saadedin, a professor from the Institute of Genetic Engineering and Biotechnologies for Postgraduate Studies at the University of Baghdad, has published a scientific research entitled: (Use of Ginger Essential Oil with Cephalosporin antibiotics as Beta-Lactamase inhibitors in pharmaceutical design to fight Escherichia coli UTI) in partnership with the researcher Yasmin J. Khalil in the scientific journal classified in Scopus database “Bionatura”.
The results showed that the isolates of E.coli of UTI from Iraqi hospitals were MDR and XDR, and their virulence was due to the presence of blaTEM genes. In silico screening, servers have been used to design an inhibitor model for Beta-Lactamases from the natural product of GEO. Cefepime and Ginger’s essential oil showed a strong synergistic effect on these bacteria, as well as the identification of E. coli of UTI isolates at the gene and species level in 46 positive samples out of a total of 50 samples. During the study, 100 samples were collected from clinical sources (urine) from patients with various urinary tract infections from several hospitals in Baghdad Governorate (Karkh) for the period from November 2021 to February 2022, through adopting traditional diagnostic methods using selective media, (CHROMagar) and (EMB agar), differential media, microscopic and biochemical tests and the Vitek-2 system, revealing a diagnostic rate of clinical isolation of 71%.
