A new genetic pattern (SNP -1218) was detected in the promoter gene region of the interleukin-10 gene in infertile Iraqi women to be used as a genetic marker in cases of the fallopian tube adhesion due to chlamydia infection with the design of special prim

Prepared by:
Assist. Prof. Dr. Shurooq Mohammed Kazim/ University of Bagdad, Genetic engineering and biotechnologies institute for postgraduate studies
 
Abstract
A new gene has been detected in promoter gene  region of interleukin-10  (-1218 SNP), which is not proven in international sites, and which may have an important and effective effect for most diseases in general and infertility among Iraqi women in particular who are infected with chlamydia .Which is one of the causes of infection in sexually transmitted diseases and it is characteristic that they live in the cells(obligate intracellular bacteria) causing in most cases chronic damage of the fallopian tube and because the patient remains infected because of the entry of bacteria in the process of hibernation which makes it difficult to be diagnosed by immunological and genetic methods sometimes.Therefore ,this mutation can be considered as a molecular indicator to assist in early diagnosis by detecting the genetic polymorphism  of the interleukin-10 gene in women through the use of this mutation as well as other internationally proven mutations (three of which are approved and are associated with most of the immunological diseases of 592 C / A , -819 C / T and -1082 A / G), including the -1082 A / G, which  related to infertility and the design of specialized primers for mutant areas for use in early molecular diagnostics.