The university of Baghdad presents a study on chromosomal deformations and gene mutations (FLT3) in cerebrospinal leukemia

The university of Baghdad presents a study on chromosomal deformations and gene mutations (FLT3) in cerebrospinal leukemia


The institute of genetic engineering and biotechnology for graduate studies at the university of Baghdad discussed one of the theses submitted on the chromosomal deformations and gene mutations (FLT3) in acute cerebrospinal leukemia. The study shed light on the effects of leukemia (AML) in some standards of cellular and molecular genetics in mononucleosis for three cases of patients including pretreatment, during treatment and after chemotherapy. The study dealt also with chromosomal deformations, formation of mini nuclei and the mutations likely to happen for patients with CN-AML in gene (FLT3/ITD) from an area of (100-300) pairs of patients compared with the healthy subjects. The sample of the study included (47) Iraqi patients with acute cerebrospinal leukemia aged (2.5 – 81) years, (20) females and (27) males. The results were compared with a sample consisting of (26) healthy subjects. The results showed that AML disease is more common in adults than in children and that 46.8 % of patients are under the age of 15 years, 90.15 % are in the ages 16-30 years, 40.9 % in those aged between 31-45 years and that rose to 90.5% in the ages above 45 years. The proportion of males of this disease is greater than that for women, 57.5 % and 42.5 %, respectively, 1.35 males, 1.0 females. Also there were two cases for patients with (Diploid), (5.3 %) of the study sample after examination with the optical microscope which is an evidence cell division (MI) in patients before taking any treatment.